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Biosimilar Characterization

HDX MS is a FDA-approved methodology to validate the structural integrity of biosimilars.
 
Additionally, HDX MS is use to as a tool for monitoring the integrity of the production process, such as batch-to-batch reproducibility and formulation stability.
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Binding Site Characterization

HDX MS is routinely utilized to identify the binding site of small molecules to proteins, as well as for the characterization of binding interfaces between protein/protein and protein/peptide complexes.
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The analysis can performed in samples containing almost any kind of biological buffers (e.g TRIS, BIS-TRIS, HEPES), and using 0.2 to 1 mg of protein.

Ligand Screening

HDX MS can be used for ligand screening by monitoring areas related to the binding site. The LC-MS and data processing are tailored to interrogate a library of compounds to a target protein.
 
The analysis can performed in samples containing almost any kind of biological buffers (e.g TRIS, BIS-TRIS, HEPES).
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